(DOWNLOAD) "Actin Polymerization in Apicomplexan" by Avinash Kale * Book PDF Kindle ePub Free
eBook details
- Title: Actin Polymerization in Apicomplexan
- Author : Avinash Kale
- Release Date : January 13, 2019
- Genre: Medical,Books,Professional & Technical,Sports & Outdoors,Science & Nature,Life Sciences,
- Pages : * pages
- Size : 10414 KB
Description
This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.
The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.
Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.